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The metabolic flux of glucose through the different pathways can be measured using stable isotope tracer methodologies and have shown to be sensitive to detect changes with treatment even before effects on glucose concentrations are identified.
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Hepatic De Novo Lipogenesis Assessment
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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development
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A First in Human, Single Ascending Dose Study to Assess the Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of AB101 in Subjects with Type 1 Diabetes​
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