About this Fact Sheet
NAFLD is an umbrella term that comprises a continuum of liver conditions that is not attributable to alcohol consumption and is broadly classified into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). NAFL is defined as hepatic steatosis with no evidence of hepatocellular injury and is associated with a low risk of adverse outcomes. An estimated 30-40% of adults in the US have NAFLD. NASH is defined as the presence of hepatic steatosis and inflammation with hepatocyte injury (ballooning) with or without fibrosis and is associated with an increased risk of progression to cirrhosis and liver transplants. An estimated 3-12% of adults in the US have NASH.
