A Randomized Crossover Trial of Mixed Meal Tolerance Test Response in People with Type 1 Diabetes on Insulin Pump Therapy and YG1699 or Dapagliflozin

Article Authors: Pablo Lapuerta, Silvia Urbina, Jiaojuan He, Alyssa Wittle, Chenghai Li, Tong Li, Helen Wang, Marcus Hompesch

Publication: Clinical Pharmacology & Therapeutics, March 2024

About This Article

An article published in Clinical Pharmacology & Therapeutics, co-authored by ProSciento and Youngene Therapeutics, discusses findings from a study that examined the effects of two different SGLT inhibitors alongside insulin in individuals with type 1 diabetes. The randomized crossover trial investigated how YG1699 and dapagliflozin influenced glucose levels in type 1 diabetes patients using pump therapy. Results show YG1699 significantly lowered post-prandial glucose levels compared to dapagliflozin, with reduced insulin dose requirements.

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