Accelerated insulin pharmacokinetics and improved postprandial glycemic control in patients with type 1 diabetes after coadministration of prandial insulins with hyaluronidase

Article Authors: Marcus Hompesch, MD, Douglas B Muchmore, MD, Linda Morrow, MD, Daniel E Vaughn, PHD


To compare the pharmacokinetics, pharmacodynamics, and safety of insulin lispro or regular human insulin (RHI) with or without recombinant human hyaluronidase (rHuPH20) administered before a standardized meal.