Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males.

Article Authors: Ensio Norjavaara, Hans Ericsson, Folke Sjöberg, Maria Leonsson-Zachrisson, Mikaela Sjöstrand, Linda A Morrow, Marcus Hompesch

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Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses to hypoglycemia are unknown.