Introduction to Glucose Clamps: Automated Versus Manual Techniques

About this Fact Sheet

The glucose clamp technique in its various forms is a well-established tool in clinical metabolic research and diabetes drug development. Both the U.S. and European regulatory authorities consider euglycemic clamps to be the ‘gold standard’ for assessing the efficacy of novel insulins. The hyperinsulinemic euglycemic clamp technique has a key role in testing novel insulin-sensitizing drugs.