Clinical Research Strategies to Drive Advances in Obesity Drug Development

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Obesity is one of the most prevalent health problems of the 21st century. Global levels of obesity have more than doubled since 1990. According to 2022 data from the World Health Organization (WHO), more than 2.5 billion adults (18 years and older) are overweight. Of these, roughly 890 million are obese (defined as a body mass index > 30 kg/m²). The Centers for Disease Control and Prevention (CDC) reports that the prevalence of obesity in U.S. adults increased from 30.5% to 41.9%, and the prevalence of severe obesity increased from 4.7% to 9.2%, over a 20-year period (from 1999–2000 through 2017–March 2020).