Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects

Article Authors: Amparo de la Peña, Matthew Riddle, Linda A Morrow, Honghua H Jiang, Helle Linnebjerg, Adam Scott, Khin M Win, Marcus Hompesch, Kenneth F Mace, Jennie G Jacobson, Jeffrey A Jackson


Human regular U-500 (U-500R) insulin (500 units/mL) is increasingly being used clinically, yet its pharmacokinetics (PK) and pharmacodynamics (PD) have not been well studied. Therefore, we compared PK and PD of clinically relevant doses of U-500R with the same doses of human regular U-100 (U-100R) insulin (100 units/mL).