Fourteen-Day Study of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in Patients with Diabetes and Hypertension

Publication Authors:

Hanrahan, J.P.; Wakefield, J.D.; Wilson, P.J.; Miller, P; Chickering, J; Morrow, L; Hall, M.L.; Currie, M; Milne, G.T.; Profy, A.T.

Presentation at American Diabetes Association (ADA) 78th Scientific Sessions, Orlando, FL, June 2018.

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Praliciguat (IW-1973), a soluble guanylate cyclase stimulator, has been shown to augment nitric oxide (NO) signaling and reduce fasting plasma glucose and proteinuria in an animal model of diabetic nephropathy. In healthy adults, repeated oral doses of 15-40 mg were tolerated and lowered blood pressure (BP).

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