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Efpeglenatide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) in development for the treatment of type 2 diabetes. The effects of efpeglenatide vs those of liraglutide and dulaglutide on glucodynamics and weight/lipid profiles were studied over 4 weeks in mouse models of diabetes (db/db) and obesity (diet-induced obesity [DIO]), respectively; doses tested were efpeglenatide 1.45, 2.89, or 4.35 nmol/kg once every 2 days (Q2D); twice-daily liraglutide 30 nmol/kg (db/db study) or 50 nmol/kg (DIO study); and dulaglutide 0.98 or 1.96 nmol/kg Q2D (human equivalent doses/key results in Table).
