Relationship Between Controlled Attenuation Parameter (CAP) and Magnetic Resonance Imaging-Derived Proton Density Fat Fraction (MRI-PDFF) in Subjects at High Risk for Nonalcoholic Fatty Liver Disease (NAFLD) - ProSciento

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Posters, Steatotic Liver Disease

Relationship Between Controlled Attenuation Parameter (CAP) and Magnetic Resonance Imaging-Derived Proton Density Fat Fraction (MRI-PDFF) in Subjects at High Risk for Nonalcoholic Fatty Liver Disease (NAFLD)

December 2019

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The use of paired liver biopsies in early phase NAFLD/NASH trials is not pragmatic due to the short nature of these studies.
MRI-PDFF is well correlated with histology‐determined steatosis in patients with NAFLD and is often used as a surrogate non-invasive biomarker of hepatic steatosis in NAFLD/NASH clinical trials.
There is, however, a need for an optimal screening strategy due to cost and timeline implications of subjects failing to meet MRI-PDFF inclusion criteria.
The assessment of CAP is easy to perform and inexpensive relative to MRI-PDFF and is currently used as a screening tool to pre-identify subjects with NAFLD.

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