Steady state is reached within two to three days of once-daily administration of degludec, a basal insulin with an ultra-long duration of action

Article Authors: Tim Heise, Stefan Korsatko, Leszek Nosek, Hans Veit Coester, Sigrid Deller, Carsten Roepstorff, Stine Segel, Rahul Kapur, Hanne Haahr, Marcus Hompesch

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Abstract

Various factors influence the pharmacokinetic and pharmacodynamic properties of insulin analogs. The aim of the present study was to determine time to steady state of insulin degludec (IDeg), a basal insulin analog with an ultralong duration of action, after once-daily subcutaneous administration in subjects of varying age, diabetes type, and ethnicity.

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