About
Insulin resistance, which may be defined as an impaired ability of insulin to modulate metabolism in target tissues, is a major therapeutic target in type 2 diabetes. In particular, accurate measurement of insulin action is necessary for the development of novel insulin-sensitizing drugs. The hyperinsulinemic euglycemic clamp, used primarily to assess insulin-mediated glucose disposal, is widely regarded as the reference method. ProSciento offers expertise in the measurement of insulin sensitivity using automated two-step hyperinsulinemic euglycemic clamp technology. This approach offers greater accuracy and less variability than manual clamps that are more operator-dependent.
![Hyperinsulinemic Euglycemic Insulin Sensitivity Clamp thumbnail](https://prosciento.com/wp-content/uploads/2021/12/thumbnail-18.png)
Recommended Materials
![Hyperinsulinemic Euglycemic Insulin Sensitivity Clamp thumbnail](https://prosciento.com/wp-content/uploads/2022/11/2019-Clamp-Quality-ProSciento-ePoster.jpg)
Posters
Glucose Clamp Quality Parameters Among Study Populations
![Hyperinsulinemic Euglycemic Insulin Sensitivity Clamp thumbnail](https://prosciento.com/wp-content/uploads/2022/01/pub-1.png)
Articles
Efficacy and safety of efpeglenatide in key patient subgroups from the BALANCE randomized trial, stratified by pre-diabetes status, BMI, and age at baseline
![Hyperinsulinemic Euglycemic Insulin Sensitivity Clamp thumbnail](https://prosciento.com/wp-content/uploads/2021/12/thumbnail-21.png)
Fact Sheets
Introduction to Glucose Clamps: Automated Versus Manual Techniques
Related Solutions
![Automated Glucose Clamp Techniques thumbnail](https://prosciento.com/wp-content/uploads/2023/08/specialized-methods-automated-glucose-clamp.jpg)
Specialized Methods
![Diabetes thumbnail](https://prosciento.com/wp-content/uploads/2023/08/our-metabolic-focus-diabetes-thumbnail.jpg)