Insulin resistance, which may be defined as an impaired ability of insulin to modulate metabolism in target tissues, is a major therapeutic target in type 2 diabetes. In particular, accurate measurement of insulin action is necessary for the development of novel insulin-sensitizing drugs. The hyperinsulinemic euglycemic clamp, used primarily to assess insulin-mediated glucose disposal, is widely regarded as the reference method. ProSciento offers expertise in the measurement of insulin sensitivity using automated two-step hyperinsulinemic euglycemic clamp technology. This approach offers greater accuracy and less variability than manual clamps that are more operator-dependent.